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SB 216763

A GSK-3 inhibitor
Catalog #: 1769
SKU-Size Size Price Qty
1769-1 1 mg
$85.00
1769-5 5 mg
$310.00
More Sizes Get Quote

Product Details

Alternate Name 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
Appearance Orange solid
CAS # 280744-09-4
Molecular Formula C₁₉H₁₂Cl₂N₂O₂
Molecular Weight 371.22
Purity ≥98% by HPLC
Solubility DMSO (50 mM)
SMILES CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C(C=C(C=C4)Cl)Cl
InChi InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)
InChi Key JCSGFHVFHSKIJH-UHFFFAOYSA-N
PubChem CID 176158
MDL Number MFCD09753369
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A potent, cell-permeable and ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3) (Ki= 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC₅₀ > 10 μM). Stimulates glycogen synthesis, gene transcription and is neuroprotective.


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