Product Details
| Alternate Name | 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione |
|---|---|
| Appearance | Orange solid |
| CAS # | 280744-09-4 |
| Molecular Formula | C₁₉H₁₂Cl₂N₂O₂ |
| Molecular Weight | 371.22 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (50 mM) |
| SMILES | CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=C(C=C(C=C4)Cl)Cl |
| InChi | InChI=1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25) |
| InChi Key | JCSGFHVFHSKIJH-UHFFFAOYSA-N |
| PubChem CID | 176158 |
| MDL Number | MFCD09753369 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
A potent, cell-permeable and ATP-competitive inhibitor of glycogen synthase kinase-3 (GSK-3) (Ki= 9 nM for GSK-3α). Has little activity against 24 other protein kinases (IC₅₀ > 10 μM). Stimulates glycogen synthesis, gene transcription and is neuroprotective.
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