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SB 202190

A potent and selective MAP Kinase inhibitor
Catalog #: 2493
SKU-Size Size Price Qty
2493-5 5 mg
$85.00
2493-25 25 mg
$335.00
More Sizes Get Quote

Product Details

Alternate Name 4-​[4-​(4-​fluorophenyl)-​5-​(4-​pyridinyl)-​1H-​imidazol-​2-​yl]-​phenol
Appearance Off-white solid
CAS # 152121-30-7
Molecular Formula C₂₀H₁₄FN₃O
Molecular Weight 331.34
Purity ≥98% by HPLC
Solubility DMSO (>30 mg/ml)
SMILES C1=CC(=O)C=CC1=C2NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F
InChi InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,23-24H
InChi Key NJNKPVPFGLGHPA-UHFFFAOYSA-N
PubChem CID 5353940
MDL Number MFCD00941964
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SB 202190 is a highly selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC₅₀ values of 50 and 100 nM, respectively. At higher concentrations (10 µM), SB 202190 displays negligible effects on several other kinases including other MAP kinases (ERKs, JNKs).


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