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Product Details
| Alternate Name | 4-[4-(4-fluorophenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]-phenol |
|---|---|
| Appearance | Off-white solid |
| CAS # | 152121-30-7 |
| Molecular Formula | C₂₀H₁₄FN₃O |
| Molecular Weight | 331.34 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (>30 mg/ml) |
| SMILES | C1=CC(=O)C=CC1=C2NC(=C(N2)C3=CC=NC=C3)C4=CC=C(C=C4)F |
| InChi | InChI=1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,23-24H |
| InChi Key | NJNKPVPFGLGHPA-UHFFFAOYSA-N |
| PubChem CID | 5353940 |
| MDL Number | MFCD00941964 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
SB 202190 is a highly selective, potent, cell-permeable inhibitor of p38 MAP kinases, inhibiting p38α (SAPK2A, MAPK14) and p38β (SAPK2B, MAPK11) with IC₅₀ values of 50 and 100 nM, respectively. At higher concentrations (10 µM), SB 202190 displays negligible effects on several other kinases including other MAP kinases (ERKs, JNKs).
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