Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

New

Savolitinib

An inhibitor of cMET tyrosine kinase
Catalog #: B3006
SKU-Size Size Price Qty
B3006-1 1 mg
$75.00
B3006-5 5 mg
$295.00
More Sizes Get Quote

Product Details

Alternate Name Volitinib; AZD 6094; HM 5016504; HMPL 504; 3-[(1S)-1-imidazo[1,2-a]pyridin-6-ylethyl]-5-(1-methylpyrazol-4-yl)triazolo[4,5-b]pyrazine; (S)-1-(1-(imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine; 4-{1-[(1S)-1-{imidazo[1,2-a]pyridin-6-yl}ethyl]-1H-[1,2,3]triazolo[4,5-b]pyrazin-6-yl}-1-methyl-1H-pyrazole
Appearance White to off-white powder
CAS # 1313725-88-0
Molecular Formula C₁₇H₁₅N₉
Molecular Weight 345.4
Purity >98%
Solubility ~16 mg/ml in DMSO
SMILES CC(C1=CN2C=CN=C2C=C1)N3C4=NC(=CN=C4N=N3)C5=CN(N=C5)C
InChi InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1
InChi Key XYDNMOZJKOGZLS-NSHDSACASA-N
PubChem CID 68289010
MDL Number MFCD28359096
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Savolitinib is an inhibitor of cMET tyrosine kinase or hepatocyte growth factor receptor (HGFR). It potently inhibits the tyrosine kinase activity of recombinant cMET in vitro with an IC₅₀ value of 4 nM. It inhibits proliferation of cell lines SNU‐5, SNU‐638, Hs746T, SNU‐620, GTL16 and IM95m with 50% effective inhibitory concentrations of 0.6 nM, 0.8 nM, 1.3 nM, 3.5 nM, 5.6 nM and 14.7 nM respectively. It shows dose‐responsive anti‐tumor efficacy in gastric cancer Hs746t xenograft model treated once‐daily (0.3 mg/kg, 1 mg/kg or 2.5 mg/kg) orally, for 16 days.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.