Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

SAR-407899 free base

A potent and selective ROCK inhibitor
Catalog #: B3356
SKU-Size Size Price Qty
B3356-5 5 mg
B3356-25 25 mg
More Sizes Get Quote

Product Details

Alternate Name 6-(piperidin-4-yloxy)isoquinolin-1(2H)-one SAR407899
Appearance Solid
CAS # 923359-38-0
Molecular Formula C₁₄H₁₆N₂O₂
Molecular Weight 244.29
Purity ≥98%
Solubility >5 mg/ml DMSO
InChi InChI=1S/C14H16N2O2/c17-14-13-2-1-12(9-10(13)3-8-16-14)18-11-4-6-15-7-5-11/h1-3,8-9,11,15H,4-7H2,(H,16,17)
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SAR-407899 is a potent and selective Rho kinase (ROCK) inhibitor with potential antihypertensive activity. SAR-407899 is equipotent against human and rat-derived Rho-kinase 2 with IC50 values of 36 nM and 41 nM, respectively. SAR407899 potently inhibits endothelin-1-induced constriction of renal resistance arteries. The antihypertensive effect of SAR-407899 is superior to that of Fasudil (Cat. No. 1787) and Y-27632 (Cat. No. 1596).

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.