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Product Details
| Alternate Name | (8S)-9-[(5-Chloropyridin-3-yl)methyl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(trifluoromethyl)-6,7,8,9a-tetrahydro-3h-pyrimido[1,2-A]pyrimidin-4-one |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 1523406-39-4 |
| Molecular Formula | C₁₉H₂₁ClFN₅O₂ |
| Molecular Weight | 443.85 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO |
| SMILES | CC1COCCN1C2=CC(=O)N3CCC(N(C3=N2)CC4=CC(=CN=C4)Cl)C(F)(F)F |
| InChi | InChI=1S/C19H21ClF3N5O2/c1-12-11-30-5-4-26(12)16-7-17(29)27-3-2-15(19(21,22)23)28(18(27)25-16)10-13-6-14(20)9-24-8-13/h6-9,12,15H,2-5,10-11H2,1H3/t12-,15+/m1/s1 |
| InChi Key | SPDQRCUBFSRAFI-DOMZBBRYSA-N |
| PubChem CID | 72709209 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
SAR-405 is a potent and selective PIK3C3/Vps34 inhibitor that prevents autophagy and synergizes with mTOR inhibition in tumor cells.
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