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A potent and selective VEGFR-3 inhibitor
Catalog #: B2592
SKU-Size Size Price Qty
B2592-5 5 mg
B2592-25 25 mg
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Product Details

Alternate Name SAR 131675, SAR131675, 2-amino-1-ethyl-7-(3-hydroxy-4-methoxy-3-methylbut-1-yn-1-yl)-N-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxamide
Peptide Sequence N/A
Appearance Crystalline solid
CAS # 1092539-44-0
Molecular Formula C₁₈H₂₂N₄O₄
Molecular Weight 358.40
Purity ≥98% by HPLC
Solubility in DMSO
InChi InChI=1S/C18H22N4O4/c1-5-22-15(19)13(17(24)20-3)14(23)12-7-6-11(21-16(12)22)8-9-18(2,25)10-26-4/h6-7,25H,5,10,19H2,1-4H3,(H,20,24)
PubChem CID 67081200
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


SAR-131675 is a potent and specific VEGFR-3 inhibitor. It inhibits VEGFR-3 tyrosine kinase activity (IC₅₀ = 20 nmol/L) and VEGFR-3 autophosphorylation (IC₅₀ = 5 nmol/L) in HEK cells, respectively. SAR-131675 is highly specific for VEGFR-3 versus 107 receptors, enzymes, ion channels, and 65 kinases. SAR131675 displays antitumoral and antimetastatic activities in vivo through inhibition of lymphangiogenesis and TAM invasion.

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