SANT-1

A potent inhibitor of Sonic hedgehog (Shh) signaling
Catalog #: 1978 | abID: ab141483

Product Details

abID ab141483
Alternate Name N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4- (phenylmethyl)-1-piperazinamine
Appearance Pale yellow solid
CAS # 304909-07-7
Molecular Formula C₂₃H₂₇N₅
Molecular Weight 373.49
Purity ≥98% by HPLC
Solubility DMSO (~50 mM) or EtOH (~25 mM)
SMILES CC1=C(C(=NN1C2=CC=CC=C2)C)C=NN3CCN(CC3)CC4=CC=CC=C4
InChi InChI=1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+
InChi Key FOORCIAZMIWALX-JJIBRWJFSA-N
PubChem CID 6878030
MDL Number MFCD01827306
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A potent inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (Kd = 1.2 nM). Inhibits smoothened agonist effects with an IC₅₀of 20 nM in Shh-LIGHT2 cells. SANT-1 inhibits both wild type and oncogenic Smo with equal potency.


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