Product Details
| abID | ab141483 |
|---|---|
| Alternate Name | N-[(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)methylene]-4- (phenylmethyl)-1-piperazinamine |
| Appearance | Pale yellow solid |
| CAS # | 304909-07-7 |
| Molecular Formula | C₂₃H₂₇N₅ |
| Molecular Weight | 373.49 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO (~50 mM) or EtOH (~25 mM) |
| SMILES | CC1=C(C(=NN1C2=CC=CC=C2)C)C=NN3CCN(CC3)CC4=CC=CC=C4 |
| InChi | InChI=1S/C23H27N5/c1-19-23(20(2)28(25-19)22-11-7-4-8-12-22)17-24-27-15-13-26(14-16-27)18-21-9-5-3-6-10-21/h3-12,17H,13-16,18H2,1-2H3/b24-17+ |
| InChi Key | FOORCIAZMIWALX-JJIBRWJFSA-N |
| PubChem CID | 6878030 |
| MDL Number | MFCD01827306 |
| Handling | Protect from light and air |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A potent inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (Kd = 1.2 nM). Inhibits smoothened agonist effects with an IC₅₀of 20 nM in Shh-LIGHT2 cells. SANT-1 inhibits both wild type and oncogenic Smo with equal potency.
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