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Sanguinarine

An inhibitor of PP2C and NF-κB
Catalog #: B2946
SKU-Size Size Price Qty
B2946-5 5 mg
$65.00
B2946-25 25 mg
$255.00
More Sizes Get Quote

Product Details

Alternate Name 13-methyl-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridin-13-ium; 13-methyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridinium; Pseudochelerythrine; Sangvinarin; Sanguinarin; Veadent; Sanguiritrin; Sanguinarium; Sangrovit; Benzophenanthridine alkaloid
Appearance Solid
CAS # 2447-54-3
Molecular Formula C₂₀H₁₄NO₄
Molecular Weight 332.33
Purity ≥98%
Solubility Soluble in DMSO
SMILES C[N+]1=C2C(=C3C=CC4=C(C3=C1)OCO4)C=CC5=CC6=C(C=C52)OCO6
InChi InChI=1S/C20H14NO4/c1-21-8-15-12(4-5-16-20(15)25-10-22-16)13-3-2-11-6-17-18(24-9-23-17)7-14(11)19(13)21/h2-8H,9-10H2,1H3/q+1
InChi Key INVGWHRKADIJHF-UHFFFAOYSA-N
PubChem CID 5154
MDL Number MFCD00064925
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Sanguinarine is a benzylisoquinoline alkaloid that inhibits PP2C and shows selectivity for PP2C over PP1, PP2A, and PP2B in vitro. It inhibits MKP-1 with an IC₅₀ of 10 μM and shows selectivity for MKP-1 over MKP-3. It is a potent suppressor of NF-κB activation and inhibits the TNF-dependent activation of NF-κB in a dose-dependent manner, with maximum effect occurring at 10 μM. It shows cytotoxicity toward human promyelocytic leukemia cell line HL60, with an IC₅₀ value of 0.37 μM.


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