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Salermide

A SIRT1 and SIRT2 inhibitor
Catalog #: 1873
SKU-Size Size Price Qty
1873-5 5 mg
$100.00
1873-25 25 mg
$415.00
More Sizes Get Quote

Product Details

Alternate Name N-​[3-​[[(2-​hydroxy-​1-​naphthalenyl)methylene]amino]phenyl]-​a-​methyl-​benzeneacetamide
Appearance Yellow solid
CAS # 1105698-15-4
Molecular Formula C₂₆H₂₂N₂O₂
Molecular Weight 394.47
Purity ≥98%
Solubility DMSO (100 mM)
SMILES CC(C1=CC=CC=C1)C(=O)NC2=CC=CC(=C2)NC=C3C(=O)C=CC4=CC=CC=C43
InChi InChI=1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,27H,1H3,(H,28,30)/b24-17-
InChi Key UADRPWLRVLBVBC-ULJHMMPZSA-N
PubChem CID 42626405
MDL Number MFCD12912446
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. Salermide is an inhibitor of SIRT1 and SIRT2. In vitro, Salermide has a stronger inhibitory effect on SIRT2 than on SIRT1. It induces massive apoptosis in tumor cells through reactivation of proapoptotic genes epigenetically repressed exclusively in cancer cells by SIRT1.


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