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SAHA

based on 3 citations in multiple journalsSAHA34.1 4
A HDAC inhibitor
Catalog #: 1604
SKU-Size Size Price Qty
1604-1 1 mg
$98.00
1604-5 5 mg
$320.00
More Sizes Get Quote

Product Details

Alternate Name Vorinostat, Suberanilohydroxamic Acid, MK-0683
Appearance White to off-white solid
CAS # 149647-78-9
Molecular Formula C₁₄H₂₀N₂O₃
Molecular Weight 264.3
Purity ≥99%
Solubility DMSO (60 mg/ml) of EtOH (2 mg/ml)
SMILES C1=CC=C(C=C1)NC(=O)CCCCCCC(=O)NO
InChi InChI=1S/C14H20N2O3/c17-13(15-12-8-4-3-5-9-12)10-6-1-2-7-11-14(18)16-19/h3-5,8-9,19H,1-2,6-7,10-11H2,(H,15,17)(H,16,18)
InChi Key WAEXFXRVDQXREF-UHFFFAOYSA-N
PubChem CID 5311
MDL Number MFCD00945317
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Potent, reversible inhibitor of histone deacetylase 1 (HDAC1) and 3 (HDAC3). Induces cell growth arrest at both G1 and G2 phases. Induces apoptosis.


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Gabriel Eades, et. al. miR-200a Regulates Nrf2 Activation by Targeting Keap1 mRNA in Breast Cancer Cells. J. Biol. Chem., Nov 2011; 286: 40725 - 40733.
Eades, G. et. al. miR-200a Regulates SIRT1 Expression and Epithelial to Mesenchymal Transition (EMT)-like Transformation in Mammary Epithelial Cells. J. Biol. Chem., Jul 2011; 286: 25992 - 26002.
Buglio, D. et. al. HDAC11 plays an essential role in regulating OX40 ligand expression in Hodgkin lymphoma. Blood, Mar 2011; 117: 2910 - 2917.
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