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SA4503 dihydrochloride

a potent sigma-1 (σ1 receptor) agonist
Catalog #: B3046
SKU-Size Size Price Qty
B3046-5 5 mg
$115.00
B3046-25 25 mg
$455.00
More Sizes Get Quote

Product Details

Alternate Name Cutamesine dihydrochloride; 1-[2-(3,4-dimethoxyphenyl)ethyl]-4-(3-phenylpropyl)piperazine;dihydrochloride; 1-(3,4-Dimethoxyphenethyl)-4-(3-phenylpropyl)piperazine 2HCl; AGY94806 dihydrochloride
Appearance White to Off-White Solid
CAS # 165377-44-6
Molecular Formula C₂₃H₃₄Cl₂N₂O₂
Molecular Weight 441.43
Purity ≥98%
Solubility ~5 mg/ml in PBS, pH 7.2; ~2 mg/ml in water
SMILES COC1=C(C=C(C=C1)CCN2CCN(CC2)CCCC3=CC=CC=C3)OC.Cl.Cl
InChi InChI=1S/C23H32N2O2.2ClH/c1-26-22-11-10-21(19-23(22)27-2)12-14-25-17-15-24(16-18-25)13-6-9-20-7-4-3-5-8-20;;/h3-5,7-8,10-11,19H,6,9,12-18H2,1-2H3;2*1H
InChi Key XWOXAKBQEMQMFH-UHFFFAOYSA-N
PubChem CID 9954941
MDL Number MFCD00939308
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

SA4503 is a potent sigma-1 (σ1 receptor) agonist. It shows 100 fold higher affinity for σ1 than σ2 receptor with IC₅₀ values of 17.4 nM and 1784 nM against 200 nM (+)-pentazocine for binding σ receptor in guinea pig brain membranes. It shows Ki values of 4.6 nM and 63.1 nM for σ1 and σ2 sites respectively in guinea pig brain homogenates. It enhances recovery of lost sensorimotor function in a rat model of stroke. Based on viral screens, modulators of sigma receptor are predicted to show activity against SARS-CoV-2.


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