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potent and selective small molecule MCL1 inhibitor
Catalog #: B1819
SKU-Size Size Price Qty
B1819-250 250 μg
B1819-1000 1 mg
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Product Details

Alternate Name (R)-2-((5-(3-chloro-2-methyl-4-(2-(4-methylpiperazin-1-yl)ethoxy)phenyl)-6-(5-fluorofuran-2-yl)thieno[2,3-d]pyrimidin-4-yl)oxy)-3-(2-((1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl)methoxy)phenyl)propanoic acid
Appearance Crystalline solid
CAS # 1799633-27-4 
Molecular Formula C₃₉H₃₇ClF₄N₆O₆S 
Molecular Weight 829.26
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C39H37ClF4N6O6S/c1-23-26(7-8-28(34(23)40)53-18-17-49-15-13-48(2)14-16-49)32-33-36(45-22-46-37(33)57-35(32)29-9-10-31(41)55-29)56-30(38(51)52)19-24-5-3-4-6-27(24)54-20-25-11-12-47-50(25)21-39(42,43)44/h3-12,22,30H,13-21H2,1-2H3,(H,51,52)
PubChem CID 126970642
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


S63845 is a potent and selective small molecule MCL1 inhibitor with Ki < 1.2 nM. S63845 potently kills MCL1-dependent cancer cells, including multiple myeloma, leukaemia and lymphoma cells, by activating the BAX/BAK-dependent mitochondrial apoptotic pathway. 

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