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(S)-H-1152 dihydrochloride

A potent, specific ATP-competitive rho-kinase (ROCK) inhibitor
Catalog #: B1106
SKU-Size Size Price Qty
B1106-1 1 mg
B1106-5 5 mg
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Product Details

Alternate Name (S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepine dihydrochloride
Appearance White Solid
CAS # 451462-58-1
Molecular Formula C₁₆H₂₁N₃O₂S.2HCl
Molecular Weight 392.34
Purity ≥98% by HPLC
Solubility DMSO (>15 mg/ml)
InChi InChI=1S/C16H21N3O2S.2ClH/c1-12-9-18-11-14-5-3-6-15(16(12)14)22(20,21)19-8-4-7-17-10-13(19)2;;/h3,5-6,9,11,13,17H,4,7-8,10H2,1-2H3;2*1H/t13-;;/m0../s1
PubChem CID 11560225
MDL Number MFCD06411451
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


H-1152 dihydrochloride is a potent, cell permeable, specific, ATP-competitive inhibitor of Rho-kinase (ROCK) (Ki = 1.6 nM).  H-1152 poorly inhibits PKA, PKC, and myosin light chain kinase (Ki = 0.63, 9.27, and 10.1 μM, respectively).

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