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Product Details
| Alternate Name | (S)-N-Methyl-3-(naphthalen-1-yloxy)-3-(thiophen-2-yl)propan-1-amine hydrochloride, Duloxetine HCl, Cymbalta |
|---|---|
| Peptide Sequence | N/A |
| Appearance | White to off-white solid |
| CAS # | 136434-34-9 |
| Molecular Formula | C18H19NOS • HCl |
| Molecular Weight | 333.88 |
| Purity | ≥97% by HPLC |
| Solubility | ~ 25 mg/ml DMSO |
| SMILES | CNCCC(C1=CC=CS1)OC2=CC=CC3=CC=CC=C32.Cl |
| InChi | InChI=1S/C18H19NOS.ClH/c1-19-12-11-17(18-10-5-13-21-18)20-16-9-4-7-14-6-2-3-8-15(14)16;/h2-10,13,17,19H,11-12H2,1H3;1H/t17-;/m0./s1 |
| InChi Key | BFFSMCNJSOPUAY-LMOVPXPDSA-N |
| PubChem CID | 60834 |
| MDL Number | MFCD06407958 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
(S)-Duloxetine hydrochloride belongs to the class of serotonin and norepinephrine reuptake inhibitors. (S)-Duloxetine suppresses spontaneous firing activity in vivo in the dorsal raphe and locus coeruleus (ED50s = 99 and 475 µg/kg, respectively). It is used to treat stress urinary incontinence, psychiatric and metabolic disorders. It is also used for treating diabetic peripheral neuropathic pain, fibromyalgia, chronic musculoskeletal and low back pain (LBP).
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