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Product Details
| Alternate Name | (S)-(-)-BAY K 8644; (-)-(S)-BayK8644; (-)-BAY-k-8644; methyl (4S)-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-3-carboxylate |
|---|---|
| Appearance | Yellow solid |
| CAS # | 98625-26-4 |
| Molecular Formula | C₁₆H₁₅F₃N₂O₄ |
| Molecular Weight | 356.3 |
| Purity | >98% |
| Solubility | ~20 mg/ml in DMSO and DMF |
| SMILES | CC1=C(C(C(=C(N1)C)[N+](=O)[O-])C2=CC=CC=C2C(F)(F)F)C(=O)OC |
| InChi | InChI=1S/C16H15F3N2O4/c1-8-12(15(22)25-3)13(14(21(23)24)9(2)20-8)10-6-4-5-7-11(10)16(17,18)19/h4-7,13,20H,1-3H3/t13-/m0/s1 |
| InChi Key | ZFLWDHHVRRZMEI-ZDUSSCGKSA-N |
| PubChem CID | 6603728 |
| MDL Number | MFCD00153769 |
| Handling | Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure. |
| Storage Conditions | -20ºC |
| Shipping Conditions | RT |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
(S)-(-)-Bay K 8644 is a L-type Ca channel agonist while R-(+)-Bay K8644 is an antagonist. (S)-(-)-Bay K 8644 causes a left shift in the Q1 (activation charge) vs. V activation curve at nanomolar concentrations in guinea-pig ventricular myocytes. The (−)-enantiomer has vasoconstricting and positive inotropic properties. (−)-Bay K 8644 also enhances the force of contraction and prolongs the action potential duration measured at 50% of repolarization in guinea-pig papillary muscles at normal resting potential. (−)-S-BAY K 8644 impairs rotarod and motor activity with an ED₅₀ value of 0.5 mg/kg in mice. It enables reprogramming of Oct4/Klf4-transduced mouse embryonic fibroblasts.
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