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S-Adenosyl-L-methionine disulfate tosylate

A cofactor for catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT)
Catalog #: 2077
SKU-Size Size Price Qty
2077-50 50 mg
2077-100 100 mg
2077-500 500 mg
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Product Details

Alternate Name AdoMet SAM disulfate p-toluenesulfonate; SAMe
Appearance White to off-white solid
CAS # 97540-22-2
Molecular Formula C₁₅H₂₂N₆O₅S.C₇H₁₂O₁₁S₂
Molecular Weight 766.8
Purity ≥95% by HPLC
Solubility H₂O (~100 mg/ml)
SMILES CC1=CC=C(C=C1)S(=O)(=O)[O-].C[S+](CCC(C(=O)O)N)CC1C(C(C(O1)N2C=NC3=C2N=CN=C3N)O)O.OS(=O)(=O)[O-].[O-]S(=O)(=O)[O-]
InChi InChI=1S/C15H22N6O5S.C7H8O3S.2H2O4S/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;1-6-2-4-7(5-3-6)11(8,9)10;2*1-5(2,3)4/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);2-5H,1H3,(H,8,9,10);2*(H2,1,2,3,4)/p-3/t7-,8+,10+,11+,14+,27?;;;/m0.../s1
PubChem CID 163657
MDL Number MFCD01674068
Handling Protect from moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A methyl donor and a cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. SAM is anti-apoptotic in normal hepatocytes and normal colon epithelial cells but pro-apoptotic in liver human hepatocellular carcinoma (HCC), HepG2 cells and colon cancer cells.

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