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S-(5'-Adenosyl)-L-methionine chloride (hydrochloride)

A methyl donor and a cofactor for catechol O-methyltransferase (COMT) and DNA methyltransferase
Catalog #: B2826
SKU-Size Size Price Qty
B2826-5 5 mg
$65.00
B2826-25 25 mg
$255.00
More Sizes Get Quote

Product Details

Alternate Name AdoMet SAM, chloride dihydrochloride, S-(5'-Adenosyl)-L-methionine chloride dihydrochloride, (3-Amino-3-carboxypropyl)(((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4, -dihydroxytetrahydrofuran-2-yl)methyl)(methyl)sulfonium chloride dihydrochloride, 5'-[[(3S)-3-amino-3-carboxypropyl]methylsulfonio]-5'-deoxy-adenosine, chloride dihydrochloride, (3-amino-3-carboxypropyl)-[[(2S,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl]-methylsulfanium;chloride;dihydrochloride
Appearance Lyophilized powder
CAS # 86867-01-8
Molecular Formula C₁₅H₂₅Cl₃N₆O₅S
Molecular Weight 507.82
Purity ≥95%
Solubility 1 mg/ml in methanol
5 mg/ml in Water
SMILES C[S+](CCC(C(=O)O)N)CC1C(C(C(O1)N2C=NC3=C2N=CN=C3N)O)O.Cl.Cl.[Cl-]
InChi InChI=1S/C15H22N6O5S.3ClH/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;;;/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);3*1H/t7?,8-,10-,11-,14-,27?;;;/m1.../s1
InChi Key KBAFOJZCBYWKPU-SPWYAPBOSA-N
PubChem CID 118821583
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -80ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SAM is a ubiquitous methyl donor. It is a cofactor for methyl transferases such as catechol O-methyltransferase (COMT) and DNA methyltransferase. Most of it is present in the liver, where 85% of all methylation reactions occur. It shows hepatoprotective effects in cultured hepatocytes and mouse models.


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