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A potent inhibitor of SET domain-containing protein 8 (SETD8)
Catalog #: B1808
SKU-Size Size Price Qty
B1808-1 1 mg
B1808-5 5 mg
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Product Details

Alternate Name 2-Methyl-5-[(4-methylphenyl)amino]-4,7-benzothiazoledione
Appearance Dark purple solid
CAS # 265312-55-8
Molecular Formula  C₁₅H₁₂N₂O₂S
Molecular Weight 284.33
Purity ≥98%
Solubility DMSO (~5 mg/ml)
InChi InChI=1S/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3
PubChem CID 481747
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Ryuvidine is a potent inhibitor of SET domain-containing protein 8 (SETD8) (IC₅₀ = 0.5 µM) that suppresses monomethylation of H4K20 in vitro. It displays weak inhibiton against cyclin-dependent kinase 4 (Cdk4; IC₅₀ = 6 µM for Cdk4/cyclin D1).  Induces S phase accumulation in HEK293T cells. Cytotoxic against a range of human cancer cells.

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