Ruxolitinib, Free base

A potent JAK inhibitor
Catalog #: 2139 | abID:

Product Details

Alternate Name INCB018424; INC18424; NCB018424; NCB18424
Appearance Off-white solid
CAS # 941678-49-5
Molecular Formula C₁₇H₁₈N₆
Molecular Weight 306.37
Purity ≥99% by HPLC
Solubility DMSO (25 mg/ml) or EtOH (~ 15 mg/ml)
InChi InChI=1S/C17H18N6/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16/h6,8-12,15H,1-5H2,(H,19,20,21)/t15-/m1/s1
PubChem CID 25126798
MDL Number MFCD12031592
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Ruxolitinib is a potent and selective Janus kinase (JAK) inhibitor with IC₅₀'s of 2.7 and 4.5 nM for JAK1 and JAK2, respectively. Displays clinically significant activity in myelofibrosis.

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