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RSK3, Active

Involved in signal transduction
Catalog #: 7774
$295.00

Product Details

Cat # +Size 7774-5
Size 5 μg
Alternate Name RSK, ribosomal protein S6 kinase, 90kDa, polypeptide 2
Gene Symbol RPS6KA2
Gene ID 6196
Accession # NM_021135.
Source Baculovirus (Sf9 insect cells)
Appearance Liquid
Physical Form Description Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Molecular Weight 112.0 kDa
Purity by SDS-PAGE ≥90%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

RSK3 is a member of the RSK (ribosomal S6 kinase) family that encodes a 733-amino-acid protein with a unique N-terminal region containing a putative nuclear localization signal (1). RSK3 mRNA is widely expressed and is activated by growth factors, serum and phorbol ester. Upon stimulation, RSK3 translocates to the cell nucleus and phosphorylates nuclear proteins. RSK3 can bind to ERK1/2 and this association increases the duration of RSK3 activation (2).


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