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RSK2, Active

Involved in signal transduction
Catalog #: 7768
$295.00

Product Details

Cat # +Size 7768-5
Size 5 μg
Alternate Name RSK, ribosomal protein S6 kinase, 90kDa, polypeptide 3, MAP kinase-activated protein kinase 1c
Gene Symbol RPS6KA3
Gene ID 6197
Accession # NM_004586.
Source Baculovirus (Sf9 insect cells)
Appearance Liquid
Physical Form Description Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 0.25mM DTT, 0.1mM EGTA, 0.1mM EDTA, 0.1mM PMSF, 25% glycerol.
Molecular Weight 112.0 kDa
Purity by SDS-PAGE ≥90%
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not to be used in humans

Details

RSK2 is a member of the RSK (ribosomal S6 kinase) family that are growth factor-regulated serine/threonine kinases. RSK2 has been shown to mediate growth factor signaling via RAS and MAPK leading to the induction of CREB serine-133 phosphorylation and activation of gene expression (1). Mutations in RSK2 have been shown to be responsible for Coffin-Lowry syndrome (CLS) which is a X-linked disorder characterized by severe psychomotor retardation, facial and digital dysmorphisms, and progressive skeletal deformations (2).


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Sun-Mi Yoo , RSK2-Mediated ELK3 Activation Enhances Cell Transformation and Breast Cancer Cell Growth by Regulation of c-fos Promoter Activity . Int J Mol Sci ;Apr 19; 31018569.
Mykhaylo V. Artamonov, RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the Na+/H+ exchanger. Sci Signal, Nov 2018; 30377223.
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