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Rottlerin

An autophagy inducer
Catalog #: 1827
$95.00

Product Details

Cat # +Size 1827-10
Size 10 mg
Alternate Name 3'-[(8-Cinnamoyl-5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-6-yl)methyl]-2',4',6'-trihydroxy-5'-methylacetophenone; Mallotoxin
Appearance Orange to brown solid
CAS # 82-08-6
Molecular Formula C₃₀H₂₈O₈
Molecular Weight 516.55
Purity ≥98% by HPLC
Solubility DMSO (30 mg/ml) or Ethanol (1 mg/ml)
SMILES CC1=C(C(=C(C(=C1O)C(=O)C)O)CC2=C(C3=C(C(=C2O)C(=O)C=CC4=CC=CC=C4)OC(C=C3)(C)C)O)O
InChi InChI=1S/C30H28O8/c1-15-24(33)19(27(36)22(16(2)31)25(15)34)14-20-26(35)18-12-13-30(3,4)38-29(18)23(28(20)37)21(32)11-10-17-8-6-5-7-9-17/h5-13,33-37H,14H2,1-4H3/b11-10+
InChi Key DEZFNHCVIZBHBI-ZHACJKMWSA-N
PubChem CID 5281847
MDL Number MFCD00017361
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Originally reported as an inhibitor of Protein Kinase C isoforms with selectivity for PKCδ. However, more recent studies have shown Rottlerin did not block PKCδ activity but did block other kinase and non-kinase proteins in vitro and activated multiple Ca²⁺-sensitive K⁺ channels with high potency. It uncouples mitochondria and affects mitochondrial production of reactive oxygen species (ROS). Also induces autophagy through inhibition of mTORC1.


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