Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

New

RORC (Human) ELISA Kit

A Sandwich ELISA kit for quantitative measurement of RORC in human serum, plasma, tissue lysates, and other biological fluids

WARNING: This product can expose you to chemicals including Sulfuric acid and TMB, which are known to the State of California to cause cancer. For more information go to www.P65Warnings.ca.gov.
Catalog #: E4993
$795.00

Product Details

Cat # +Size E4993-100
Size 96 assays
Detection Method Absorbance (450 nm)
Species Reactivity Human
Applications Sandwich ELISA kit to quantitatively measure RORC in human serum, plasma, tissue lysate, and other biological fluids
Features & Benefits ● This Sandwich ELISA is highly sensitive and highly specific for the detection of RORC in human samples. There is no significant cross-reactivity or interference between RORC and analogues
● Detection range: 0.156 – 10 ng/ml
● Assay Precision: Intra-Assay CV and Inter-Assay CV < 10%
● Recovery range: 85 - 105% for normal human serum and plasma samples
● Sensitivity: 0.094 ng/ml
Kit Components ● Micro ELISA plate
● Wash Buffer (25X)
● Plate Sealers
● Standard (Lyophilized) (10 ng)
● Sample/Standard Dilution Buffer
● Biotin-labeled Antibody
● Antibody Dilution Buffer
● HRP-Streptavidin Conjugate (SABC)
● SABC Dilution Buffer
● TMB Substrate Solution
● Stop Solution
Storage Conditions 4ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

RAR-related Orphan Receptor C (RORC, RORG) is a DNA binding transcription factor that belongs to the retinoic acid-related orphan receptor (ROR) family that includes ROR alpha and ROR beta. RORC is expressed in several tissues such as the liver, lung, kidney, thymus, heart, and muscle. The mRNA expression of RORC is either circadian (in liver and kidney) or constitutive (in muscles). Some of the major functions of RORC are to mediate the differentiation of Th17 cells, develop lymph nodes, regulate glucose/lipid metabolism, adipocyte differentiation, and insulin sensitivity. RORC also regulates circadian rhythms. It competes with NR1D1 (Rev-ErbA) for binding to the ROR elements (ROREs) in the Bmal1 promoter and positively regulates Bmal1 transcription. Some RORC agonists (LYC-55716 and INV-71) are currently under investigation as novel immunotherapeutic agents to treat various cancers. BioVision’s RORC (Human) ELISA kit quantitatively measures RORC in human serum, plasma, and other biological fluids. Test samples, Standards, and Biotinylated Detection antibody are added to the wells pre-coated with capture antibody and then washed with Wash Buffer. HRP-Streptavidin is added to the plate, and post-incubation any unattached conjugates are washed off by Wash Buffer. The HRP enzymatic reaction is detected using TMB-substrate. Finally, an acidic stop solution terminates the enzymatic reaction. The color developed is directly proportional to the amount of RORC in the sample or standard.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.