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Rocaglamide

An immunosuppressant
Catalog #: 1863
$365.00

Product Details

Cat # +Size 1863-100
Size 100 µg
Alternate Name Rocaglamide A
Appearance White to off-white solid
CAS # 84573-16-0
Molecular Formula C₂₉H₃₁NO₇
Molecular Weight 505.56
Purity ≥98% by HPLC
Solubility DMSO or EtOH
SMILES CN(C)C(=O)C1C(C2(C(C1O)(C3=C(C=C(C=C3O2)OC)OC)O)C4=CC=C(C=C4)OC)C5=CC=CC=C5
InChi InChI=1S/C29H31NO7/c1-30(2)27(32)23-24(17-9-7-6-8-10-17)29(18-11-13-19(34-3)14-12-18)28(33,26(23)31)25-21(36-5)15-20(35-4)16-22(25)37-29/h6-16,23-24,26,31,33H,1-5H3/t23-,24-,26-,28+,29+/m1/s1
InChi Key DAPAQENNNINUPW-IDAMAFBJSA-N
PubChem CID 331783
MDL Number MFCD08702699
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

An immunosuppressant and a potent inhibitor of NF-κB activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-γ, TNF-α, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-κB and AP-1 activities. Also induces mitochondria-mediated apoptosis in leukemia cells and sensitizes CD95/CD95L-mediated apoptosis in malignant T-cells by differential regulation of CD95L and c-FLIP expression.


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