A small-molecule chemical inhibitor of Sonic hedgehog (Shh) signaling
Catalog #: 1923 | abID:

Product Details

Cat # +Size 1923-1
Size 1 mg
Alternate Name N-[(4-Chlorophenyl)methyl]-2-[(2R,6S,8E)-5, 12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide
Appearance White solid
CAS # 1132653-79-2
Molecular Formula C₂₅H₂₇ClN₂O₄
Molecular Weight 454.95
Purity ≥97% by NMR
Solubility DMSO
InChi InChI=1S/C25H27ClN2O4/c26-21-13-11-18(12-14-21)16-27-23(29)15-20-9-5-2-6-10-24(30)32-22(17-28-25(20)31)19-7-3-1-4-8-19/h1-5,7-8,11-14,20,22H,6,9-10,15-17H2,(H,27,29)(H,28,31)/b5-2+/t20-,22-/m0/s1
PubChem CID 25109985
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A small-molecule chemical inhibitor of Sonic hedgehog (Shh) signaling, that blocks hedgehog signaling through specific binding and blockade of Shh signaling factor. It is the first-characterized hedgehog inhibitor whose molecular mechanism of action is through blockade of Shh protein and not a subsequent factor of the hedgehog signaling cascades. Robotnikinin binds to the Shh-N terminal protein in a concentration-dependent fashion with a Kd of 9 µM.

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