Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

Robotnikinin

A small-molecule chemical inhibitor of Sonic hedgehog (Shh) signaling
Catalog #: 1923
$295.00

Product Details

Cat # +Size 1923-1
Size 1 mg
Alternate Name N-[(4-Chlorophenyl)methyl]-2-[(2R,6S,8E)-5, 12-dioxo-2-phenyl-1-oxa-4-azacyclododec-8-en-6-yl]acetamide
Appearance White solid
CAS # 1132653-79-2
Molecular Formula C₂₅H₂₇ClN₂O₄
Molecular Weight 454.95
Purity ≥97% by NMR
Solubility DMSO
SMILES C1CC(=O)OC(CNC(=O)C(CC=C1)CC(=O)NCC2=CC=C(C=C2)Cl)C3=CC=CC=C3
InChi InChI=1S/C25H27ClN2O4/c26-21-13-11-18(12-14-21)16-27-23(29)15-20-9-5-2-6-10-24(30)32-22(17-28-25(20)31)19-7-3-1-4-8-19/h1-5,7-8,11-14,20,22H,6,9-10,15-17H2,(H,27,29)(H,28,31)/b5-2+/t20-,22-/m0/s1
InChi Key DRDSZZCLAHXSAE-BQIDRLATSA-N
PubChem CID 25109985
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A small-molecule chemical inhibitor of Sonic hedgehog (Shh) signaling, that blocks hedgehog signaling through specific binding and blockade of Shh signaling factor. It is the first-characterized hedgehog inhibitor whose molecular mechanism of action is through blockade of Shh protein and not a subsequent factor of the hedgehog signaling cascades. Robotnikinin binds to the Shh-N terminal protein in a concentration-dependent fashion with a Kd of 9 µM.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.