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RO4929097

A potent γ-secretase inhibitor
Catalog #: 2011

In stock

SKU-Size Size Price Qty
2011-1 1 mg
$100.00
2011-5 5 mg
$395.00
More Sizes Get Quote

Product Details

Appearance Off-white solid
CAS # 847925-91-1
Molecular Formula C₂₂H₂₀F₅N₃O₃
Molecular Weight 469.4
Purity ≥98% by HPLC
Solubility DMSO
SMILES CC(C)(C(=O)NCC(C(F)(F)F)(F)F)C(=O)NC1C2=CC=CC=C2C3=CC=CC=C3NC1=O
InChi InChI=1S/C22H20F5N3O3/c1-20(2,18(32)28-11-21(23,24)22(25,26)27)19(33)30-16-14-9-4-3-7-12(14)13-8-5-6-10-15(13)29-17(16)31/h3-10,16H,11H2,1-2H3,(H,28,32)(H,29,31)(H,30,33)/t16-/m0/s1
InChi Key OJPLJFIFUQPSJR-INIZCTEOSA-N
PubChem CID 49867930
MDL Number MFCD18384976
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

RO4929097 is a small molecule γ-secretase inhibitor (IC₅₀ = 4 nM). It binds to γ-secretase and blocks the activation of Notch receptors, which may inhibit tumor cell proliferation. RO4929097 inhibits Notch processing in tumor cells as measured by the reduction of intracellular Notch expression by Western blot. RO4929097 produces a less transformed and flattened slower-growing phenotype but does not induce apoptosis or block tumor cell proliferation.


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