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Ro 31-8220 methanesulfonate

A potent PKC inhibitor
Catalog #: 1946
SKU-Size Size Price Qty
1946-1 1 mg
$80.00
1946-5 5 mg
$305.00
More Sizes Get Quote

Product Details

Alternate Name 2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate; Bisindolylmaleimide IX methanesulfonate; BIM IX
Appearance Red solid
CAS # 138489-18-6
Molecular Formula C₂₅H₂₃N₅O₂S.CH₄O₃S
Molecular Weight 553.65
Purity ≥98% by NMR
Solubility DMSO (~ 100 mg/ml) or water (~ 5 mg/ml)
SMILES CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O
InChi InChI=1S/C25H23N5O2S.CH4O3S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20;1-5(2,3)4/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32);1H3,(H,2,3,4)
InChi Key SAWVGDJBSPLRRB-UHFFFAOYSA-N
PubChem CID 11628205
MDL Number MFCD03788207
Handling Protect from light and air
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isoforms (IC₅₀ = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively). It inhibits protein kinase A (PKA) (IC₅₀ = 0.9 μM) and calcium/calmodulin kinase II (IC₅₀ = 17 μM) at much higher concentrations. Also inhibits glycogen synthase kinase-3 (GSK-3) (IC₅₀ = 6.8 nM).


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