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Product Details
| Alternate Name | 2-{1-[3-(Amidinothio)propyl]-1H-indol-3-yl}-3-(1-methylindol-3-yl)maleimide methanesulfonate; Bisindolylmaleimide IX methanesulfonate; BIM IX |
|---|---|
| Appearance | Red solid |
| CAS # | 138489-18-6 |
| Molecular Formula | C₂₅H₂₃N₅O₂S.CH₄O₃S |
| Molecular Weight | 553.65 |
| Purity | ≥98% by NMR |
| Solubility | DMSO (~ 100 mg/ml) or water (~ 5 mg/ml) |
| SMILES | CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCSC(=N)N.CS(=O)(=O)O |
| InChi | InChI=1S/C25H23N5O2S.CH4O3S/c1-29-13-17(15-7-2-4-9-19(15)29)21-22(24(32)28-23(21)31)18-14-30(11-6-12-33-25(26)27)20-10-5-3-8-16(18)20;1-5(2,3)4/h2-5,7-10,13-14H,6,11-12H2,1H3,(H3,26,27)(H,28,31,32);1H3,(H,2,3,4) |
| InChi Key | SAWVGDJBSPLRRB-UHFFFAOYSA-N |
| PubChem CID | 11628205 |
| MDL Number | MFCD03788207 |
| Handling | Protect from light and air |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Cell-permeable. A potent bisindolylmaleimide inhibitor of protein kinase C (PKC) isoforms (IC₅₀ = 5, 24, 14, 27, and 24 nM for PKC-α, PKC-βI, PKC-βII, PKC-γ, and PKC-ε, respectively). It inhibits protein kinase A (PKA) (IC₅₀ = 0.9 μM) and calcium/calmodulin kinase II (IC₅₀ = 17 μM) at much higher concentrations. Also inhibits glycogen synthase kinase-3 (GSK-3) (IC₅₀ = 6.8 nM).
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