Product Details
| Alternate Name | 6-Cyclopropyl-8-fluoro-2-[2-(hydroxymethyl)-3-[1-methyl-5-[[5-(4-methylpiperazin-1-yl)pyridin-2-yl]amino]-6-oxopyridin-3-yl]phenyl]isoquinolin-1-one |
|---|---|
| Appearance | Crystalline solid |
| CAS # | 1242156-23-5 |
| Molecular Formula | C₃₅H₃₅FN₆O₃ |
| Molecular Weight | 606.69 |
| Purity | ≥98% by HPLC |
| Solubility | DMSO |
| SMILES | CN1CCN(CC1)C2=CN=C(C=C2)NC3=CC(=CN(C3=O)C)C4=C(C(=CC=C4)N5C=CC6=CC(=CC(=C6C5=O)F)C7CC7)CO |
| InChi | InChI=1S/C35H35FN6O3/c1-39-12-14-41(15-13-39)26-8-9-32(37-19-26)38-30-18-25(20-40(2)34(30)44)27-4-3-5-31(28(27)21-43)42-11-10-23-16-24(22-6-7-22)17-29(36)33(23)35(42)45/h3-5,8-11,16-20,22,43H,6-7,12-15,21H2,1-2H3,(H,37,38) |
| InChi Key | ZTUJNJAKTLHBEX-UHFFFAOYSA-N |
| PubChem CID | 46908026 |
| Handling | Protect from air and light |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
RN486 is a potent Bruton's tyrosine kinase (Btk) inhibitor (IC₅₀ = 4 nM). When tested with human Ramos B cells or whole blood, RN486 treatment reduces the expression of CD69/B cells proliferation and IgG production by blocking BCR and FcR Signaling
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