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RN 1 dihydrochloride

A cell-permeable, lysine specific demethylase 1 (LSD1) inhibitor
Catalog #: B2080
SKU-Size Size Price Qty
B2080-5 5 mg
B2080-25 25 mg
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Product Details

Alternate Name 1-(4-methyl-1-piperazinyl)-2-[[(1R*,2S*)-2-[4-phenylmethoxy)phenyl]cyclopropyl]amino]ethanone dihydrochloride
Appearance White solid
CAS # 1781835-13-9
Molecular Formula C₂₃H₂₉N₃O₂.2HCl
Molecular Weight 452.42
Purity ≥97%
Solubility DMSO (~8 mg/ml) or H₂O (~8 mg/ml)
InChi InChI=1S/C23H29N3O2.2ClH/c1-25-11-13-26(14-12-25)23(27)16-24-22-15-21(22)19-7-9-20(10-8-19)28-17-18-5-3-2-4-6-18;;/h2-10,21-22,24H,11-17H2,1H3;2*1H/t21-,22+;;/m0../s1
PubChem CID 90488995
Handling Protect from air and moisture
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


RN 1 dihydrochloride is a potent, cell-permeable, lysine specific demethylase 1 (LSD1) inhibitor (IC₅₀ = 70 nM). Displays selectivity for LSD1 over MAO-A and MAO-B (IC₅₀ values are 0.51 and 2.79 μM for MAO-A and MAO-B, respectively). Impairs long-term, but not short-term memory in mice.

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