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A potent, selective and allosteric SHP2 inhibitor
Catalog #: B2752
SKU-Size Size Price Qty
B2752-5 5 mg
B2752-25 25 mg
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Product Details

Alternate Name RMC4550; (3-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl)methanol
Peptide Sequence N/A
Appearance White to off-white solid
CAS # 2172651-73-7
Molecular Formula C₂₁H₂₆Cl₂N₄O₂
Molecular Weight 437.36
Purity ≥98%
Solubility >100 mg/ml DMSO
SMILES ClC1=C(Cl)C(C2=NC(CO)=C(N3CCC4(CO[[email protected]@H](C)[[email protected]]4N)CC3)N=C2C)=CC=C1
InChi InChI=1S/C21H26Cl2N4O2/c1-12-18(14-4-3-5-15(22)17(14)23)26-16(10-28)20(25-12)27-8-6-21(7-9-27)11-29-13(2)19(21)24/h3-5,13,19,28H,6-11,24H2,1-2H3/t13-,19+/m0/s1
InChi Key ClC1=C(Cl)C(C2=NC(CO)=C(N3CCC4(CO[[email protected]@H](C)[[email protected]]4N)CC3)N=C2C)=CC=C1
PubChem CID 134183206
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


RMC-4550 is a potent, selective and allosteric inhibitor of SHP2 (IC50 = 0.583 nM). RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide, but lacks activity against the free catalytic domain of SHP2.

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