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RKI-1447

A highly potent ROCK1 and ROCK2 inhibitor
Catalog #: 2472
SKU-Size Size Price Qty
2472-5 5 mg
$95.00
2472-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl urea
Appearance Yellow solid
CAS # 1342278-01-6
Molecular Formula C₁₆H₁₄N₄O₂S
Molecular Weight 326.37
Purity ≥98% by HPLC
Solubility DMSO (>50 mg/ml)
SMILES O=C(NCC1=CC=CC(O)=C1)NC2=NC(C3=CC=NC=C3)=CS2
InChi InChI=1S/C16H14N4O2S/c21-13-3-1-2-11(8-13)9-18-15(22)20-16-19-14(10-23-16)12-4-6-17-7-5-12/h1-8,10,21H,9H2,(H2,18,19,20,22)
InChi Key GDVRVPIXWXOKQO-UHFFFAOYSA-N
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A highly potent inhibitor of Rho-associated kinases ROCK1 and ROCK2 (IC₅₀ values: 14.5 nM for ROCK1 and 6.2 nM for ROCK2). RKI-1447 suppresses ROCK-dependent signaling, cell morphology, anchorage-independent cell growth, migration invasion and in vivo growth of mammary tumors.


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