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Ritonavir

An orally bioavailable HIV-1 and HIV-2 protease inhibitor
Catalog #: B2140

In stock

SKU-Size Size Price Qty
B2140-10 10 mg
$75.00
B2140-50 50 mg
$225.00
More Sizes Get Quote

Product Details

Alternate Name (3S,4S,6S,9S)-4-hydroxy-12-methyl-9-(1-methylethyl)-13-[2-(1-methylethyl)-4-thiazolyl]-8,11-dioxo-3,6-bis(phenylmethyl)-2,7,10,12-tetraazatridecanoic acid, 5-thiazolylmethyl ester; ABT-538; NSC 693184
Appearance White solid
CAS # 155213-67-5
Molecular Formula C₃₇H₄₈N₆O₅S₂
Molecular Weight 720.94
Purity ≥98% by HPLC
Solubility DMSO (>10 mg/ml with slight warming)
SMILES CC(C)C1=NC(=CS1)CN(C)C(=O)NC(C(C)C)C(=O)NC(CC2=CC=CC=C2)CC(C(CC3=CC=CC=C3)NC(=O)OCC4=CN=CS4)O
InChi InChI=1S/C37H48N6O5S2/c1-24(2)33(42-36(46)43(5)20-29-22-49-35(40-29)25(3)4)34(45)39-28(16-26-12-8-6-9-13-26)18-32(44)31(17-27-14-10-7-11-15-27)41-37(47)48-21-30-19-38-23-50-30/h6-15,19,22-25,28,31-33,44H,16-18,20-21H2,1-5H3,(H,39,45)(H,41,47)(H,42,46)/t28-,31-,32-,33-/m0/s1
InChi Key NCDNCNXCDXHOMX-XGKFQTDJSA-N
PubChem CID 392622
MDL Number MFCD00927142
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Ritonavir is an orally bioavailable HIV-1 and HIV-2 protease inhibitor (EC₅₀ values are 0.022-0.13 and 0.16 μM, respectively). Through CYP3A4 inhibition, low doses of ritonavir can reduce the metabolism of concomitantly administered protease inhibitors, enhancing their bioavailability and efficacy.


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