Call 408.493.1800 | Fax 408.493.1801 | Toll Free 800.891.9699 (US Only) | Email: [email protected]

New

Ripretinib

An inhibitor of receptor tyrosine kinase (KIT) and platelet derived growth factor receptor A (PDGFRA)
Catalog #: B3106
SKU-Size Size Price Qty
B3106-1 1 mg
$65.00
B3106-5 1 mg
$260.00
More Sizes Get Quote

Product Details

Alternate Name N-{4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3- yl]-2-fluorophenyl}-N'-phenylurea; DCC-2618; 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea
Appearance White to off-white powder
CAS # 1442472-39-0
Molecular Formula C₂₄H₂₁BrFN₅O₂
Molecular Weight 510.4
Purity ≥ 98%
Solubility ~30 mg/ml in DMSO (may need ultrasonication)
SMILES CCN1C2=CC(=NC=C2C=C(C1=O)C3=CC(=C(C=C3Br)F)NC(=O)NC4=CC=CC=C4)NC
InChi InChI=1S/C24H21BrFN5O2/c1-3-31-21-12-22(27-2)28-13-14(21)9-17(23(31)32)16-10-20(19(26)11-18(16)25)30-24(33)29-15-7-5-4-6-8-15/h4-13H,3H2,1-2H3,(H,27,28)(H2,29,30,33)
InChi Key CEFJVGZHQAGLHS-UHFFFAOYSA-N
PubChem CID 71584930
MDL Number MFCD31657437
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Ripretinib is an inhibitor of receptor tyrosine kinase (KIT) and platelet derived growth factor receptor A (PDGFRA). In vitro kinase inhibition studies show that ripretinib inhibits wild-type KIT and PDGFRA with IC₅₀ values of 3 and 3.6 nM. It is approved for the treatment of adult patients with advanced gastrointestinal stromal tumour who have received prior treatment with 3 kinase inhibitors.


Why buy BioVision Products?
Innovation
Affordability
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.