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An inhibitor of receptor tyrosine kinase (KIT) and platelet derived growth factor receptor A (PDGFRA)
Catalog #: B3106
SKU-Size Size Price Qty
B3106-1 1 mg
B3106-5 1 mg
More Sizes Get Quote

Product Details

Alternate Name N-{4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3- yl]-2-fluorophenyl}-N'-phenylurea; DCC-2618; 1-[4-bromo-5-[1-ethyl-7-(methylamino)-2-oxo-1,6-naphthyridin-3-yl]-2-fluorophenyl]-3-phenylurea
Appearance White to off-white powder
CAS # 1442472-39-0
Molecular Formula C₂₄H₂₁BrFN₅O₂
Molecular Weight 510.4
Purity ≥ 98%
Solubility ~30 mg/ml in DMSO (may need ultrasonication)
InChi InChI=1S/C24H21BrFN5O2/c1-3-31-21-12-22(27-2)28-13-14(21)9-17(23(31)32)16-10-20(19(26)11-18(16)25)30-24(33)29-15-7-5-4-6-8-15/h4-13H,3H2,1-2H3,(H,27,28)(H2,29,30,33)
PubChem CID 71584930
MDL Number MFCD31657437
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Ripretinib is an inhibitor of receptor tyrosine kinase (KIT) and platelet derived growth factor receptor A (PDGFRA). In vitro kinase inhibition studies show that ripretinib inhibits wild-type KIT and PDGFRA with IC₅₀ values of 3 and 3.6 nM. It is approved for the treatment of adult patients with advanced gastrointestinal stromal tumour who have received prior treatment with 3 kinase inhibitors.

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