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Ripasudil hydrochloride dihydrate

A potent Rho kinase (ROCK) inhibitor
Catalog #: B2984
SKU-Size Size Price Qty
B2984-1 1 mg
$95.00
B2984-5 5 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name 4-fluoro-5-[[(2S)-2-methyl-1,4-diazepan-1-yl]sulfonyl]isoquinoline, dihydrate, hydrochloride; K-115 Hydrochloride Dihydrate; 1H-1,4-Diazepine, 1-((4-fluoro-5-isoquinolinyl)sulfonyl)hexahydro-2-methyl-, monohydrochloride, dihydrate
Appearance White powder
CAS # 887375-67-9
Molecular Formula C₁₅H₂₃ClFN₃O₄S
Molecular Weight 395.88
Purity 99%
Solubility 50 mg/ml in Water
SMILES CC1CNCCCN1S(=O)(=O)C2=CC=CC3=CN=CC(=C32)F.O.O.Cl
InChi InChI=1S/C15H18FN3O2S.ClH.2H2O/c1-11-8-17-6-3-7-19(11)22(20,21)14-5-2-4-12-9-18-10-13(16)15(12)14;;;/h2,4-5,9-11,17H,3,6-8H2,1H3;1H;2*1H2/t11-;;;/m0.../s1
InChi Key CMDJNMACGABCKQ-XVSRHIFFSA-N
PubChem CID 11625386
MDL Number MFCD26960897
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.

Details

Ripasudil (K-115) is a potent inhibitor of Rho kinase (ROCK), with IC₅₀ values of 19 and 51 nM for ROCK-2 and ROCK-1, respectively. Ripasudil (10 μM) induces cytoskeletal changes, including retraction, cell rounding and reduced actin bundles of cultured trabecular meshwork (TM) cells. It significantly reduces transendothelial electrical resistance (TEER) and increases FITC-dextran permeability in Schlemm’s canal endothelial (SCE) cell monolayers at a concentration of 5 μM. A 0.4% ophthalmic solution significantly lowers intraocular pressure (IOP) in rabbits and monkeys. It was the first ophthalmic solution developed for the treatment of glaucoma and ocular hypertension in Japan.


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