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A highly potent and selective inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase
Catalog #: B3051
SKU-Size Size Price Qty
B3051-5 5 mg
B3051-25 25 mg
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Product Details

Alternate Name N-benzyl-N-hydroxy-2,2-dimethylbutanamide
Appearance White to beige powder
CAS # 1956370-21-0
Molecular Formula C₁₃H₁₉NO₂
Molecular Weight 221.29
Purity ≥98%
Solubility ~2 mg/ml in DMSO
InChi InChI=1S/C13H19NO2/c1-4-13(2,3)12(15)14(16)10-11-8-6-5-7-9-11/h5-9,16H,4,10H2,1-3H3
PubChem CID 121439991
MDL Number MFCD30738006
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of Receptor-Interacting Protein 1 (RIP1) kinase with an IC₅₀ of 13 nM. It protects HT-29 cells against TNFα-induced necroptosis with an EC₅₀ of 28 nM. RIPA-56 efficiently reduces TNFα-induced mortality and multiorgan damage in a systemic inflammatory response syndrome (SIRS) mice model. Modulators of RIP kinase 1 may be beneficial against SARS-CoV-2 based on interaction of RIP kinase 1 with SARS-CoV-2 protein Nsp12.

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