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Rigosertib

A potent, specific PLK1 (Polo -Like Kinase 1) inhibitor
Catalog #: 9482
SKU-Size Size Price Qty
9482-5 5 mg
$125.00
9482-25 25 mg
$485.00
More Sizes Get Quote

Product Details

Alternate Name Sodium (E)-2-((2-methoxy-5-(((2,4,6-trimethoxystyryl)sulfonyl)methyl)phenyl)amino)acetate; ON-01910
Appearance White solid
CAS # 1225497-78-8
Molecular Formula C₂₁H₂₄NNaO₈S
Molecular Weight 473.47
Purity ≥98% by HPLC
Solubility DMSO (>5 mg/ml)
SMILES COC1=C(C=C(C=C1)CS(=O)(=O)C=CC2=C(C=C(C=C2OC)OC)OC)NCC(=O)[O-].[Na+]
InChi InChI=1S/C21H25NO8S.Na/c1-27-15-10-19(29-3)16(20(11-15)30-4)7-8-31(25,26)13-14-5-6-18(28-2)17(9-14)22-12-21(23)24;/h5-11,22H,12-13H2,1-4H3,(H,23,24);/q;+1/p-1/b8-7+;
InChi Key VLQLUZFVFXYXQE-USRGLUTNSA-M
PubChem CID 23696523
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Rigosertib is a potent, specific PLK1 (Polo -Like Kinase 1) inhibitor (IC₅₀ = 9 nM). Rigosertib strongly inhibits the proliferation of cancer cell lines, with observed IC₅₀ values in the nanomolar range for both HeLa (115 nM) and C33A (45 nM) cells. In contrast, Rigosertib has a minimal effect on normal cell lines, BJ and Ect1/E6E7 (IC₅₀ > 0.1 mM).


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