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Ribociclib (LEE011)

A potent cyclin-dependent kinase (CDK) inhibitor
Catalog #: 9481
SKU-Size Size Price Qty
9481-5 5 mg
$95.00
9481-25 25 mg
$375.00
More Sizes Get Quote

Product Details

Alternate Name 7-cyclopentyl-N,N-dimethyl-2-((5-(piperazin-1-yl)pyridin-2-yl)amino)-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide
Appearance Yellow solid
CAS # 1211441-98-3
Molecular Formula C₂₃H₃₀N₈O
Molecular Weight 434.54
Purity ≥98% by HPLC
Solubility DMSO (~10 mg/ml)
SMILES CN(C)C(=O)C1=CC2=CN=C(N=C2N1C3CCCC3)NC4=NC=C(C=C4)N5CCNCC5
InChi InChI=1S/C23H30N8O/c1-29(2)22(32)19-13-16-14-26-23(28-21(16)31(19)17-5-3-4-6-17)27-20-8-7-18(15-25-20)30-11-9-24-10-12-30/h7-8,13-15,17,24H,3-6,9-12H2,1-2H3,(H,25,26,27,28)
InChi Key RHXHGRAEPCAFML-UHFFFAOYSA-N
PubChem CID 44631912
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Ribociclib is a potent cyclin-dependent kinase (CDK) inhibitor targeting cyclin D1/CDK4 and cyclin D3/CDK6 cell cycle pathway, with potential antineoplastic activity. LEE011 has been shown to reduce proliferation in 12 of 17 human neuroblastoma-derived cell lines by inducing cytostasis (mean IC₅₀ = 306 nM in sensitive lines).


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