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Rhein

Catalog #: B2737
SKU-Size Size Price Qty
B2737-50 50 mg
$95.00
B2737-250 250 mg
$350.00
More Sizes Get Quote

Product Details

Alternate Name NSC-38629; 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthracenecarboxylic acid
Peptide Sequence N/A
Appearance Yellow solid
CAS # 478-43-3
Molecular Formula C₁₅H₈O₆
Molecular Weight 284.22
Purity ≥95%
Solubility ~10 mg/ml DMSO
SMILES C1=CC2=C(C(=C1)O)C(=O)C3=C(C2=O)C=C(C=C3O)C(=O)O
InChi InChI=1S/C15H8O6/c16-9-3-1-2-7-11(9)14(19)12-8(13(7)18)4-6(15(20)21)5-10(12)17/h1-5,16-17H,(H,20,21)
InChi Key FCDLCPWAQCPTKC-UHFFFAOYSA-N
PubChem CID 10168
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Rhein is an anthraquinone derivative that displays diverse biological activities, including anticancer, antioxidant, and anti-inflammatory activities. Also acts as a Fat mass and obesity-associated protein FTO (mRNA N6-methyladenine demethylase) inhibitor (IC50 = 1.2 - 21 μM; Ki = 1.8 μM). Also inhibits ALKBH3 and ALKBH2 (IC50 values are 5.3 and 9.1 μM, respectively). Sensitizes glioblastoma cells to alkylating agents.


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