Reversine

An A3 adenosine receptor antagonist
Catalog #: 1851 | abID:

Product Details

Alternate Name 2-(4-Morpholinoanilino)-6-cyclohexylaminopurine
Appearance Off-white solid
CAS # 656820-32-5
Molecular Formula C₂₁H₂₇N₇O
Molecular Weight 393.49
Purity ≥98% by TLC
Solubility DMSO (~7-10 mg/ml)
SMILES C1CCC(CC1)NC2=NC(=NC3=C2NC=N3)NC4=CC=C(C=C4)N5CCOCC5
InChi InChI=1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27)
InChi Key ZFLJHSQHILSNCM-UHFFFAOYSA-N
PubChem CID 210332
MDL Number MFCD07784513
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

A cell-permeable, potent, and selective human A3 adenosine receptor antagonist (Ki = 0.66 μM) and an aurora kinase inhibitor (IC₅₀'s of 30-550 nM for blast colony formation assay). Induces dedifferentiation in murine C2C12 myoblasts. The cells were also shown to regain multipluripotency following removal of the compound.


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