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Resminostat (hydrochloride)

An inhibitor of HDAC
Catalog #: B2852
SKU-Size Size Price Qty
B2852-5 5 mg
B2852-25 25 mg
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Product Details

Alternate Name 3-[1-[[4-[(dimethylamino)methyl]phenyl]sulfonyl]-1H-pyrrol-3-yl]-N-hydroxy-2-propenamide, monohydrochloride; 4SC-201 hydrochloride; RAS2410 hydrochloride; (E)-3-[1-(4-dimethylaminomethyl-benzenesulfonyl)-1H-pyrrol-3-yl]-N-hydroxy-acrylamide hydrochloride
Appearance Crystalline solid
CAS # 1187075-34-8
Molecular Formula C₁₆H₂₀ClN₃O₄S
Molecular Weight 385.87
Purity >98% (HPLC)
Solubility ~0.5 mg/ml in PBS, pH 7.2
~10 mg/ml in DMSO
~0.5 mg/ml in DMF
InChi InChI=1S/C16H19N3O4S.ClH/c1-18(2)11-13-3-6-15(7-4-13)24(22,23)19-10-9-14(12-19)5-8-16(20)17-21;/h3-10,12,21H,11H2,1-2H3,(H,17,20);1H/b8-5+;
PubChem CID 16662815
Handling Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Storage Conditions -20ºC
Shipping Conditions RT
USAGE For Research Use Only! Not For Use in Humans.


Resminostat is a potent inhibitor of histone deacetylases (HDAC) 1, 3 and 6 with IC₅₀ ranging from 43–72 nM. It induces hyperacetylation of histone H4, abrogates cell growth and induces apoptosis in multiple myeloma cells with an IC₅₀ of 2.5-3 µM. It inhibits cell proliferation, induces G0/G1 cell cycle arrest, decreases levels of cyclin D1, cdc25a, Cdk4 and pRb and upregulates p21.

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