A Toll-like receptor 7 (TLR-7) agonist
Catalog #: 1699 | abID:

Product Details

Alternate Name 1-[4-amino-2-(ethoxymethyl)imidazo[4,5-c]quinolin-1-yl]-2-methylpropan-2-ol; R-848
Appearance White to off-white solid
CAS # 144875-48-9
Molecular Formula C₁₇H₂₂N₄O₂
Molecular Weight 314.38
Purity ≥98% by HPLC
Solubility DMSO
InChi InChI=1S/C17H22N4O2/c1-4-23-9-13-20-14-15(21(13)10-17(2,3)22)11-7-5-6-8-12(11)19-16(14)18/h5-8,22H,4,9-10H2,1-3H3,(H2,18,19)
PubChem CID 159603
MDL Number MFCD00937759
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


A selective ligand for Toll-like receptor 7 (TLR7) in mouse and for TLR7 and TLR8 in humans. Displays antitumor and antiviral properties. Stimulates antibody secretion, cytokine production, protection from apoptosis and CD80 upregulation.

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Falaleeva et al., FRI0184 Dendritic Cells as a Potential Object in Cellular Immunotherapy in Rheumatoid Arthritis. Ann Rheum Dis, Jun 2015; 74: 490 - 491.
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