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RepSox

based on 1 citations in multiple journalsRepSox14.1 4
A TGF-β type I receptor (ALK5) inhibitor
Catalog #: 1894
SKU-Size Size Price Qty
1894-5 5 mg
$90.00
1894-25 25 mg
$325.00
More Sizes Get Quote

Product Details

Alternate Name 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine; E-616452
Appearance Off-white solid
CAS # 446859-33-2
Molecular Formula C₁₇H₁₃N₅
Molecular Weight 287.32
Purity ≥98% by HPLC
Solubility DMSO (>20 mg/ml)
SMILES CC1=CC=CC(=N1)C2=C(C=NN2)C3=NC4=C(C=C3)N=CC=C4
InChi InChI=1S/C17H13N5/c1-11-4-2-5-16(20-11)17-12(10-19-22-17)13-7-8-14-15(21-13)6-3-9-18-14/h2-10H,1H3,(H,19,22)
InChi Key LBPKYPYHDKKRFS-UHFFFAOYSA-N
PubChem CID 449054
MDL Number MFCD09037561
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Cell-permeable. A TGF-β type I receptor (ALK5) inhibitor. Inhibits ALK5 autophosphorylation (IC₅₀ = 4 nM). Can replace one of the four reprogramming factors Sox-2. RepSox has been successfully used in the direct reprogramming of mouse fibroblasts through induction of Nanog transcription.


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Hu et al., Direct Conversion of Normal and Alzheimer's Disease Human Fibroblasts into Neuronal Cells by Small Molecules. Cell Stem Cell Aug 2015, 17:204–212.
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