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Product Details
| Cat # +Size | K799-100 |
|---|---|
| Size | 100 assays |
| Detection Method | Fluorescence (Ex/Em = 328/552 nm) |
| Applications | Screening potential inhibitors of renin Characterize/study renin inhibitors |
| Features & Benefits | • Rapid & simple • Reliable test for screening potential inhibitors of renin • Includes Inhibitor Control [Aliskiren] |
| Kit Components | • Renin Assay Buffer • Renin Substrate • Active Human Renin (lyophilized) (15 µg) • Inhibitor Control [Aliskiren] (200 µM) |
| Storage Conditions | -80°C |
| Shipping Conditions | Dry Ice |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
Renin (EC 3.4.23.15), also known as an angiotensinogenase, is an enzyme that participates in the renin-angiotensin system (RAS) which mediates extracellular volume (i.e. blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. An over-active renin-angiotensin system leads to vasoconstriction and retention of sodium and water, causing hypertension. Renin inhibitors are widely used for the treatment of hypertension. BioVision’s Renin inhibitor screening Kit uses a synthetic peptide substrate with a fluorophore (EDANS) at one end and a quencher (DABCYL) at the other end. Renin catalyzes the cleavage of FRET substrate resulting in a product that is detected fluorometrically at Ex/Em = 328/552 nm. In the presence of a Renin inhibitor, the rate of hydrolysis of the substrate is decreased. The kit provides a rapid, simple, sensitive, and reliable test suitable for high throughput screening of Renin inhibitors also adaptable to a 384 well format.
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