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Renin Inhibitor Screening Kit (Fluorometric)

Sensitive Assay to Screen Renin Inhibitors, HTS
Catalog #: K799
$520.00

Product Details

Cat # +Size K799-100
Size 100 assays
Detection Method Fluorescence (Ex/Em = 328/552 nm)
Applications Screening potential inhibitors of renin
Characterize/study renin inhibitors
Features & Benefits • Rapid & simple
• Reliable test for screening potential inhibitors of renin
• Includes Inhibitor Control [Aliskiren]
Kit Components • Renin Assay Buffer
• Renin Substrate
• Active Human Renin (lyophilized) (15 µg)
• Inhibitor Control [Aliskiren] (200 µM)
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not For Use in Humans.

Details

Renin (EC 3.4.23.15), also known as an angiotensinogenase, is an enzyme that participates in the renin-angiotensin system (RAS) which mediates extracellular volume (i.e. blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. An over-active renin-angiotensin system leads to vasoconstriction and retention of sodium and water, causing hypertension. Renin inhibitors are widely used for the treatment of hypertension. BioVision’s Renin inhibitor screening Kit uses a synthetic peptide substrate with a fluorophore (EDANS) at one end and a quencher (DABCYL) at the other end. Renin catalyzes the cleavage of FRET substrate resulting in a product that is detected fluorometrically at Ex/Em = 328/552 nm. In the presence of a Renin inhibitor, the rate of hydrolysis of the substrate is decreased. The kit provides a rapid, simple, sensitive, and reliable test suitable for high throughput screening of Renin inhibitors also adaptable to a 384 well format.


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