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Remodelin

A N-acetyltransferase 10 (NAT10) inhibitor
Catalog #: 9411
SKU-Size Size Price Qty
9411-5 5 mg
$90.00
9411-25 25 mg
$355.00
More Sizes Get Quote

Product Details

Alternate Name 4-​[2-​(2-​cyclopentylidenehydrazinyl)-​4-​thiazolyl]-​benzonitrile
Appearance White to off-white solid
CAS # 949912-58-7
Molecular Formula C₁₅H₁₄N₄S
Molecular Weight 282.36
Purity ≥98% by HPLC
Solubility DMSO (~ 15 mg/ml)
SMILES C1CCC(=NNC2=NC(=CS2)C3=CC=C(C=C3)C#N)C1
InChi InChI=1S/C15H14N4S/c16-9-11-5-7-12(8-6-11)14-10-20-15(17-14)19-18-13-3-1-2-4-13/h5-8,10H,1-4H2,(H,17,19)
InChi Key XAEJIFARBQJLML-UHFFFAOYSA-N
PubChem CID 44442376
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Remodelin is a potent and selective inhibitor of the acetyl-transferase protein NAT10 that mediates nuclear shape rescue in laminopathic (LMNA-depleted) cells via microtubule reorganization. Remodelin markedly reduces the prevalence of misshapen nuclei in HGPS cells as well as in primary MRC5 fibroblasts aged in culture. In contrast, Remodelin has no effect on nonlaminopathic Werner syndrome cells.


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