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Regorafenib

A multi-kinase inhibitor
Catalog #: 2891
SKU-Size Size Price Qty
2891-5 5 mg
$125.00
2891-25 25 mg
$495.00
More Sizes Get Quote

Product Details

Alternate Name 4-(4-(3-(4-chloro-3-(trifluoromethyl)phenyl)ureido)-3-fluorophenoxy)-N-methylpicolinamide; BAY 73-4506
Appearance Off-white solid
CAS # 755037-03-7
Molecular Formula C₂₁H₁₅ClF₄N₄O₃
Molecular Weight 482.81
Purity ≥98% by HPLC
Solubility DMSO (>50 mg/ml)
SMILES CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F
InChi InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
InChi Key FNHKPVJBJVTLMP-UHFFFAOYSA-N
PubChem CID 11167602
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

Regorafenib is a multi-kinase inhibitor targeting angiogenic (VEGFR, TIE-2), stromal (PDGFR-β) and oncogenic (RAF, RET and c-KIT) receptor tyrosine kinases, with IC₅₀s of 17, 40 and 69 nM for c-KIT, VEGFR2, B-Raf, respectively. Displays potential antiangiogenic and antineoplastic activities.


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