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A highly selective and potent orally available inhibitor of MEK 1 and MEK 2.
Catalog #: B1889
SKU-Size Size Price Qty
B1889-5 5 mg
B1889-25 25 mg
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Product Details

Alternate Name N-[3,4-difluoro-2-(2-fluoro-4-iodoanilino)-6-methoxyphenyl]-1-[(2S)-2,3-dihydroxypropyl]cyclopropane-1-sulfonamide; BAY 86-9766
Appearance Crystalline solid
CAS # 923032-37-5
Molecular Formula C₁₉H₂₀F₃IN₂O₅S
Molecular Weight 572.34
Purity ≥98% by HPLC
Solubility DMSO (>5 mg/ml)
InChi InChI=1S/C19H20F3IN2O5S/c1-30-15-7-13(21)16(22)18(24-14-3-2-10(23)6-12(14)20)17(15)25-31(28,29)19(4-5-19)8-11(27)9-26/h2-3,6-7,11,24-27H,4-5,8-9H2,1H3/t11-/m0/s1
PubChem CID 44182295
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.


Refametinib (BAY 86-9766; previously RDEA119) is a highly selective and potent orally available inhibitor of MEK 1 and MEK 2.  It displays potent in vitro and in vivo antitumor activity in multiple preclinical cancer models, including melanoma, colorectal cancer, non-small cell lung cancer, epidermal carcinoma, and HCC.

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