Recombinant SARS-CoV-2 Papain-like Protease

Replicase polyprotein essential for generating a functional replication complex
Catalog #: P1551 | abID:

Product Details

Alternate Name PLPro, PL-PRO, pp1a, Papain-like Protease, Replicase polyprotein 1a, ORF1a polyprotein, Plpro
Accession # YP_009725299.1
Source E. coli
Appearance Sterile Filtered colorless solution
Physical Form Description Liquid
Molecular Weight 38 kDa (6×His tag at the N-terminus)
Purity by >95%
Endotoxin Level < 1.0 EU/μg of the protein by LAL method.
Amino Acid Sequence aa Glu1564-Lys1878
Handling Centrifuge the vial prior to opening.
Storage Conditions -80°C
Shipping Conditions Dry Ice
USAGE For Research Use Only! Not For Use in Humans.


SARS-CoV is an enveloped, single and positive-stranded RNA virus. Replication of the genomic RNA of SARS-CoV is mediated by replicase polyproteins that are processed by two viral proteases, papain-like protease (PLpro) and 3C-like protease (3CLpro). The chymotrypsin-like 3CLpro processes the replicase polyprotein at 11 sites, including cleaving itself from the polyprotein to generate a ∼25-kDa protease product. Papain-like proteases have been shown to process the amino-terminal end of the replicase polyprotein to generate two or three replicase products. Proteolytic processing of the coronavirus replicase polyprotein is essential for generating a functional replication complex. Therefore, the coronavirus replicase-encoded proteases, 3CLpro and PLpro, are potential targets for antiviral drug development.

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