Product Details
| Cat # +Size | P1670-50 |
|---|---|
| Size | 50 μg |
| Alternate Name | RNA-directed RNA polymerase, RdRp, RdRp catalytic domain, nsp12, SARS-CoV-2 NSP12; COVID-19 NSP12; 2019-nCoV NSP12; Non-Structural Protein 12; nsp12 |
| Accession # | QHD43415.1 |
| Source | E.coli |
| Appearance | Lyophilized protein |
| Molecular Weight | 39.4 kDa |
| Purity by SDS-PAGE | ≥ 90% |
| Reconstitution Instructions | Reconstitute in sterile water to a concentration of 1 mg/ml. |
| Amino Acid Sequence | The target protein is expressed with the sequence Asp4891-Val5212 of SARS-CoV-2 NSP12 with a His tag at the C-terminus. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not For Use in Humans. |
Details
The replication of Coronavirus is operated by multiple non-structural proteins (nsps). The viral genomic RNA is translated from two open reading frames (ORFs), ORF1a and ORF1b. The encoded replicase polyproteins, pp1a and pp1ab, are further processed to produce nsps. NSP12 encoded by ORF1b has the viral RNA-dependent RNA polymerase (RdRp) motif. It is the catalytic core of the RNA replicase.
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