Recombinant Human Soluble Interleukin-6 (IL-6) Receptor

>98% Pure, Active, Human Recombinant Soluble Interleukin-6 (IL-6) Receptor
Catalog #: 4598 | abID: ab245952

Product Details

abID ab245952
Cat # +Size 4598-20
Size 20 µg
Alternate Name soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126
Gene Symbol IL6R
Gene ID 3570
Accession # P08887
Source CHO cells
Appearance Lyophilized
Physical Form Description Lyophilized from 1X PBS, pH 7.2
Molecular Weight 37.6 kDa
Purity by SDS-PAGE ≥98%
Biological Activity The ED50 as determined by its ability to intensify the IL-6 induced growth inhibition of murine M1 cells is <5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6.
Reconstitution Instructions Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex.
Handling Centrifuge the vial prior to opening.
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not to be used in humans


The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component specific to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related cytokines, i.e. LIF, OSM, CNTF, IL-11 and CT-1. The low affinity binding sites for IL-6 is composed of IL-6R alpha alone. At low concentrations, soluble IL-6R alpha acts as an agonist of IL-6 activity. Recombinant human sIL-6R alpha is a 37.6 kDa protein, consisting of the extra cellular domain of the sIL-6R alpha chain (338 amino acids).

Why buy BioVision Products?
Global Presence
Technical Support
BioVision aims to provide our customers innovative tools for accelerating drug discovery and biological research. BioVision offers >8,000 products including the most comprehensive array of assay kits for key targets in Metabolic pathways.
BioVision is committed to providing the highest quality products at a competitive price.
We have a broad network of global distributors who are ready to address your research needs and ensure fast delivery.
Our highly trained Technical Support team provides comprehensive product support and is dedicated to resolving your issues quickly and efficiently.