Product Details
| abID | ab245952 |
|---|---|
| Cat # +Size | 4598-20 |
| Size | 20 µg |
| Alternate Name | soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126 |
| Gene Symbol | IL6R |
| Gene ID | 3570 |
| Accession # | P08887 |
| Source | CHO cells |
| Appearance | Lyophilized |
| Physical Form Description | Lyophilized from 1X PBS, pH 7.2 |
| Molecular Weight | 37.6 kDa |
| Purity by SDS-PAGE | ≥98% |
| Biological Activity | The ED50 as determined by its ability to intensify the IL-6 induced growth inhibition of murine M1 cells is <5.0 ng/ml, in the presence of 20 ng/ml of rhIL-6. |
| Reconstitution Instructions | Centrifuge the vial prior to opening. Reconstitute in PBS, pH 7.4. Do not vortex. |
| Handling | Centrifuge the vial prior to opening. |
| Storage Conditions | -20°C |
| Shipping Conditions | Gel Pack |
| USAGE | For Research Use Only! Not to be used in humans |
Details
The IL-6 receptor system consists of two chains, IL-6R alpha and gp130. The IL-6R alpha is the binding component specific to the IL-6, but does not transduce a signal alone. On the contrary, gp130 transmits signals not only of IL-6, but also IL-6 related cytokines, i.e. LIF, OSM, CNTF, IL-11 and CT-1. The low affinity binding sites for IL-6 is composed of IL-6R alpha alone. At low concentrations, soluble IL-6R alpha acts as an agonist of IL-6 activity. Recombinant human sIL-6R alpha is a 37.6 kDa protein, consisting of the extra cellular domain of the sIL-6R alpha chain (338 amino acids).
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