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Recombinant Human SIRT 1

Protein deacetylase that links transcriptional regulation directly to intracellular energetics
Catalog #: P1675
SKU-Size Size Price Qty
P1675-10 10 µg
$145.00
P1675-50 50 µg
$345.00
More Sizes Get Quote

Product Details

Alternate Name Sirtuin 1, SIR2L1, hSIRT1, EC 2.3.1.286, NAD-dependent protein deacylase sirtuin-1, Regulatory protein SIR2 homolog 1, SIR2-like protein 1
Gene ID 23411
Accession # Q96EB6
Source Insect cells
Appearance Sterile Filtered colorless solution
Molecular Weight 63.0 kDa (aa 193 to 747, calculated with N-terminal His tag)
Purity by SDS-PAGE ≥95%
Formulation 50 mM sodium phosphate pH 7.5, 300 mM NaCl, 0.1 mM PMSF, and 0.25 mM DTT in 35% glycerol
Specific Activity > 1,000 µU/mg
Unit Definition One unit of SIRT1 activity is the amount of enzyme that hydrolyzes the substrate to yield 1.0 µmol of AFC/min when using BioVision’s Sirtuin Activity Assay Kit, Cat. No. K324.
Handling Centrifuge the vial prior to opening.
Storage Conditions -70°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

Details

SIRT1 is a member of the sirtuin family of proteins, which are homologs to the yeast Sir2 protein. The sirtuin family contains a sirtuin core domain and is grouped into four classes with SIRT1 being a member of class I. SIRT1 is a stress-response and chromatin silencing factor. It is an NAD dependent histone deacetylase involved in various nuclear events such as transcription, DNA replication, and DNA repair. SIRT1 protein binds and deacetylates the p53 protein. Expression of wild type SIRT1 in human cells reduces the transcriptional activity of p53, indicating SIRT1 is involved in the regulation of p53 function via deacetylation. SIRT1 has also been shown to regulate the circadian expression of several core clock genes, and may contribute to the regulation of the circadian rhythm.


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